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  1. Read more: The Functional Fragrance Brain Map: Which Compounds Target Which Brain Structures
    The Functional Fragrance Brain Map: Which Compounds Target Which Brain Structures

    The Functional Fragrance Brain Map: Which Compounds Target Which Brain Structures

    Functional fragrance works because specific compounds act on specific brain structures via the olfactory pathway. This page maps each functional ingredient in CALM, FOCUS, and GROUND to its primary brain target, the mechanism of action, and the functional outcome. α-Santalol targets the hypothalamus for HPA axis modulation. 1,8-Cineole targets the basal forebrain and prefrontal cortex for adenosine receptor modulation and AChE inhibition. Vetiver targets the hippocampus and superior colliculus for orienting response activation. The most precise publicly available documentation of neuroperfumery at the compound level.
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