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Burnout isn't exhaustion—it's a nervous system state, specifically a prolonged failure of the stress-recovery cycle that collapses the system's capacity to regulate itself. Rest doesn't fix it because rest isn't the opposite of burnout; regulation is. The physiological markers: sustained elevated cortisol that eventually gives way to cortisol depletion, reduced vagal tone, impaired HRV, and a nervous system that has learned to stay in dorsal vagal withdrawal as a protective response to chronic overload.